Products Description
Piroxicam beta cyclodextrin
Piroxicam β cyclodextrin
PBCD
Appearance: Power
Color: yellowish
Standard: In-house Standard
CAS NO.: 96684-39-8
Product Description:
Piroxicam- Beta-Cyclodextrin is made by enwrapping medical piroxicam and medical beta-cyclodextrin in a certain inverse proportion with a unique art.
This inclusion compound has less odor, more stability and more stable medicine releasing speed than the single piroxicam.
Piroxicam-beta-cyclodextrin is mainly used in anti-inflammatory analgesic drugs. It is more useful in the medical.
Item
Name | Piroxicam beta cyclodextrin |
CAS No. | 96684-39-8 |
Molecular Formula | C42 H70 O35 . x C15 H13 N3 O4 S |
Color of Solution | 0.50g/100ml water solution is light yellow |
Content of Piroxicam | 9.5％-11.5% |
Package | 10kg/drum,25kg/drum |
Water solution pH | pH5.0~8.0 |
Storage | Preserve in well-closed containers. |
Test Standard | Enterprise Standard |
Appearance | This product should be light yellow powder, odorless, tasteless. |
Identification | The retention time of the major peak of sample solution corresponds to the standard solution. |
Water solution pH | pH5.0~8.0 |
Color of Solution | 0.50g/100ml water solution is light yellow. |
Ammonium Ion | ≤0.5% |
Free Piroxicam | ≤0.5% |
Loss on Drying | ≤6.0% |
Content of Piroxicam | 9.5%~11.5% |
Packaging and storage | Preserve in well-closed containers. |
Features and applications
It also known as inflammatory pain piroxicam beta-cyclodextrin is a process unique, according to a certain proportion of the pharmaceutical grade of piroxicam with pharmaceutical grade B-cyclodextrin inclusion is refined, the inclusion complexes with piroxicam monomer phase comparison, has less odor, more stable, more stable medicine releasing speed, mainly used in anti-inflammatory analgesic drugs.
Pharmacological mechanism and action
Target: inhibit cyclooxygenase (COX) activity, reduce prostaglandin synthesis, and exert analgesic, anti-inflammatory and antipyretic effects.
Indications: mild to moderate pain (such as arthritis, muscle aches). Acute periodontitis, oral inflammation such as post-tooth extraction pain.
Advantages: Compared with piroxicam monomer, the inclusion complex of piroxicam beta-cyclodextrin has lower odor, more stable drug release characteristics, and reduces gastrointestinal irritation.
Application areas
Medical field: piroxicam beta-cyclodextrin is used as an excipient for anti-inflammatory and analgesic drugs, and is used in tablets (such as β-cyclodextrin piroxicam tablets), gels and other dosage forms. Prolong the shelf life of active ingredients in drugs and improve the stability of preparations.
Industrial use: as an intermediate or excipient to optimize the production process.